Table 1.
Demographic and biochemical characteristics of the studied subjects.
| Factor | Control (n = 8) |
T2DM (n = 9) |
p-value |
|---|---|---|---|
| Age (yr) | 48.9 ± 12.7 | 59.3 ± 9.1 | 0.07 |
| Body mass index (kg/m2) | 28.7 ± 3.3 | 31.2 ± 3.5 | 0.15 |
| Glucose (mg/dl) | 92.5 ± 11.9 | 113.3 ± 14.3 | 0.005 |
| Insulin (mIU/dl) | 8.5 ± 4.7 | 19.0 ± 7.9 | 0.005 |
| HOMA IR | 1.9 ± 1.04 | 5.3 ± 2.0 | < 0.001 |
| HbA1c(%) | 5.5 ± 0.24 | 6.3 ± 0.32 | < 0.001 |
| Triglycerides (mg/dl) | 96.1 ± 40.7 | 100.1 ± 37.3 | 0.84 |
| hsCRP (mg/l) | 1.5 ± 1.1 | 5.3 ± 4.6 | 0.15 |
| Cp (mg/dl) | 19.3 ± 2.8 | 21.1 ± 3.2 | 0.25 |
| Cp ferroxidase activity (µM/min) | 530.9 ± 64.7 | 538.8 ± 27.8 | 0.74 |
| Serum copper (µg/dl) | 72.3 ± 9.0 | 68.6 ± 13.7 | 0.57 |
| Serum iron (µg/dl) | 78.3 ± 32.6 | 78.4 ± 28.5 | 0.99 |
| Ferritin (ng/ml) | 76.3 ± 36.7 | 144.1 ± 8.5 | 0.10 |
| Trf (g/l) | 2.57 ± 0.35 | 2.52 ± 0.43 | 0.94 |
| Trf unsaturated iron-binding capacity (µg/dl) | 216.3 ± 66.1 | 215.0 ± 66.3 | 0.97 |
| Trf total iron-binding capacity (µg/dl) | 294.6 ± 39.8 | 293.4 ± 44.7 | 0.96 |
| Trf iron saturation | 0.28 ± 0.12 | 0.28 ± 0.13 | 0.94 |
| Cp/Trf ratio | 7.7 ± 1.2 | 8.6 ± 1.2 | 0.21 |
| TBARS (µM) | 0.48 ± 0.16 | 0.43 ± 0.08 | 0.43 |
| Anti-oxidant capacity of plasma (RFU/µl/min) | 37.2 ± 8.2 | 33.7 ± 7.1 | 0.45 |
Statistics presented as mean ± SD. p-Values are from Student's t-test.
Cp: ceruloplasmin, HbA1c: glycated hemoglobin, HOMA IR: homeostatic model assessment of insulin resistance, hsCRP: high-sensitivity C-reactive protein, RFU: relative fluorescence unit, TBARS: thiobarbituric acid reactive substances, Trf: serotransferrin.