TABLE 5.
The association between anti-HCV/HCV RNA status and all-cause mortality among 9117 NHANES III participants aged 18–59 years by sex
| Anti-HCV negative | Anti-HCV positive (RNA positive and negative) | Anti-HCV and HCV RNA positive (chronic HCV) | |||
|---|---|---|---|---|---|
|
|
|
||||
| MRR (95% CI) | P-value | MRR (95% CI) | P-value | ||
| Women | |||||
|
| |||||
| Total number (N) | 4947 | 102 | 77 | ||
|
| |||||
| All-cause mortality (n) | 385 | 25 | 20 | ||
|
| |||||
| Age adjusted | 1.00 [Reference] | 4.72 (2.56–8.69) | <.0001 | 5.98 (3.4–10.50) | <.001 |
|
| |||||
| Partially adjustedb | 1.00 [Reference] | 2.52 (1.20–5.25) | .01 | 3.11 (1.50–6.43) | .002 |
|
| |||||
| Fully adjustedc | 1.00 [Reference] | 2.37 (1.04–5.39) | .04 | 2.97 (1.24–7.10) | .01 |
|
| |||||
| Men | |||||
|
| |||||
| Total number (N) | 3919 | 149 | 126 | ||
|
| |||||
| All-cause mortality (n) | 476 | 44 | 40 | ||
|
| |||||
| Age adjusted | 1.00 [Reference] | 3.35 (1.91–5.89) | <.0001 | 4.03 (2.23–7.30) | <.001 |
|
| |||||
| Partially adjustedb | 1.00 [Reference] | 2.40 (1.28–4.48) | .006 | 2.90 (1.61–5.22) | .0004 |
|
| |||||
| Fully adjustedc | 1.00 [Reference] | 2.09 (1.09–4.00) | .03 | 2.49 (1.31–4.72) | .005 |
a
Mortality rate ratio (95% confidence interval) versus anti-HCV negative.
b
Partial adjustment: demographics (age, race/ethnicity, marital status, education, poverty income ratio), lifestyle (alcohol consumption, smoking status, lifetime cocaine and marijuana use, lifetime number of sexual partners), body mass index and comorbidities/viruses (cancer, diabetes, hepatitis A antibody, hepatitis E antibody).
c
Full adjustment factors: partial adjustment factors, liver function biomarkers (ALT, total bilirubin).