TABLE 6.
The association between anti-HCV/HCV RNA status and all-cause mortality among 9117 NHANES III participants aged 18–59 years by age group
| Anti-HCV negative | Anti-HCV positive (RNA positive and negative) | Anti-HCV and HCV RNA positive (chronic HCV) | |||
|---|---|---|---|---|---|
|
|
|
||||
| MRR (95% CI) | P-value | MRR (95% CI) | P-value | ||
| 18–40 y | |||||
|
| |||||
| Total number (N) | 5860 | 169 | 136 | ||
|
| |||||
| All-cause mortality (n) | 276 | 35 | 29 | ||
|
| |||||
| Sex adjusted | 1.00 [Reference] | 3.26 (1.70–6.26) | <.001 | 3.50 (1.65–7.46) | .001 |
|
| |||||
| Partially adjustedb | 1.00 [Reference] | 1.90 (0.92–3.94) | .08 | 2.13 (0.99–4.56) | .05 |
|
| |||||
| Fully adjustedc | 1.00 [Reference] | 1.55 (0.77–3.11) | .22 | 1.62 (0.80–3.26) | .18 |
|
| |||||
| 41–59 y | |||||
|
| |||||
| Total number (N) | 3006 | 82 | 67 | ||
|
| |||||
| All-cause mortality (n) | 585 | 34 | 31 | ||
|
| |||||
| Sex adjusted | 1.00 [Reference] | 3.81 (2.26–6.42) | <.001 | 4.90 (2.98–8.07) | <.001 |
|
| |||||
| Partially adjustedb | 1.00 [Reference] | 3.21 (1.72–6.00) | <.001 | 4.17 (2.39–7.29) | <.001 |
|
| |||||
| Fully adjustedc | 1.00 [Reference] | 3.28 (1.63–6.57) | <.001 | 4.76 (2.50–9.10) | <.001 |
a
Mortality rate ratio (95% confidence interval) versus anti-HCV negative.
b
Partial adjustment: demographics (sex, race/ethnicity, marital status, education, poverty income ratio), lifestyle (alcohol consumption, smoking status, lifetime cocaine and marijuana use, lifetime number of sexual partners), body mass index and comorbidities/viruses (cancer, diabetes, hepatitis A antibody, hepatitis E antibody).
c
Full adjustment factors: partial adjustment factors, liver function biomarkers (ALT, total bilirubin).