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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Liver Res. 2017 Aug 9;1(2):81–87. doi: 10.1016/j.livres.2017.08.002

Fig. 2. AA or CCl4 administration causes periportal or central lobular proliferation, respectively.

Fig. 2

AA (7.4 mg/kg) and CCl4 (300 mg/kg) were administered to rats through IP injection for 45 days. BrdU (100 mg/kg body weight) was injected into animals 2 hours before sacrifice. H&E staining was performed to monitor histological changes in damaged livers. Proliferating cells were labeled with monoclonal mouse BrdU antibody followed by 3, 3’-diaminobenzidine (DAB) detection. Arrowheads indicate proliferating cells and damaged areas. Scale bar: 100 µm. PV: portal vein; CV: central vein.