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A combination of toxicity phenotyping, transcriptomics, chromatin state analyses, and genetic variability in a population-based model allow exploration of Gene×Environment×Epigenome interactions. Abbreviations: eQTL, expression quantitative trait loci; cQTL, chromatin QTL; ecQTLs, environmental chromatin QTL; toxQTL, toxicity QTL; eeQTL, environmental expression QTL.
