Table 2. Multivariable model hazard ratios for time to first breakthrough seizure after a period of 12-month remission whilst on treatment.
| Variable | Comparison | Multivariable HR (95% CI) |
|---|---|---|
| Neurological insult as recorded at randomisation | Absent | 1.00 |
| Present | 1.55 (1.21, 1.98) | |
| Total number of tonic-clonic seizures recorded before achieving 12-month remission | 0 | 1.00 |
| 1 | 1.03 (1.02, 1.04) | |
| 2 | 1.07 (1.04, 1.10) | |
| 3–4 | 1.10 (1.06, 1.15) | |
| 5–6 | 1.14 (1.07, 1.20) | |
| 7–10 | 1.17 (1.09, 1.25) | |
| 11–20 | 1.22 (1.12, 1.33) | |
| >20 | 1.56 (1.28, 1.90) | |
| Time taken to achieve 12-month remission following randomisation (years) | 1 | 1.00 |
| 1–1.5 | 1.27 (1.16, 1.39) | |
| 1.5–2 | 1.56 (1.32, 1.84) | |
| 2–3 | 1.74 (1.42, 2.14) | |
| >3 | 1.87 (1.49, 2.36) |
HR>1 suggests breakthrough seizure more likely
Italic results are statistically significant