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. 2017 Dec 21;12(12):e0189922. doi: 10.1371/journal.pone.0189922

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© 2017 Jafari et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — (A) The 1965 and the present-day Central Dogma editions in molecular biology (B) The initial four-node Central Dogma wiring diagram formed by DNA, mRNA, Protein and Activator. (C) The present-day seven-node Central Dogma wiring diagram formed by DNA, mRNA, Protein, Activator, miRNA, DegProtein and DegRNA. The directed edge “—o” represents a functional relationship with both activatory and inhibitory effects (D) Network representation of Boolean rules corresponding to the simple 1965 model. (E) Network representation of Boolean rules corresponding to the present-day updated model. For simplicity, the first version of each model is shown.