Table 1. Boolean rules governing the state of the 4-node network of the 1965 proposed central dogma depicted in Fig 1B derived from [1, 2].

The symbols “&”, “|” and “!” represent “AND”, “OR” and “NOT” operators.

		Logical rule
Node	Definition	V1: Activatory gene expression	V2: Inhibitory gene expression
Activator	The chemical molecules which facilitate active protein production during or after translation	Activator
DNA	The genes transcribed to coding RNA	DNA
mRNA	The coding RNA	DNA & Protein	DNA &! Protein
Protein	The functional active protein	(mRNA & Activator) | Protein