Fig 4. Alcohol intake and preference in the two-bottle free-choice paradigm.

Alcohol A) intake and B) preference during the 14 weeks of alcohol access in the two-bottle free-choice (20% alcohol and water) paradigm on the modified intermittent access schedule (three days of alcohol, four days of water only), with an alcohol deprivation period week 7–8. The alcohol consumption was measured every 24 h during alcohol access, and averaged for the three access days in a week. Data are presented as medians with interquartile range for the whole population (n = 40), and by rearing condition × supplier (n = 10/group). 1 p<0.05, 11 <0.01, 111 <0.001 compared to week 1; 666 p<0.001 compared to week 6; 999 p< 0.001 compared to week 9 (post hoc Wilcoxon’s test).