Table 2. Effect of unilateral nephrectomy on renal histologic damage after ischemia-reperfusion injury.
| Sham | UNx | IR | IR+UNx | |
|---|---|---|---|---|
| Cortical casts | 0 | 0 | 1.2 ± 0.17 | 1.6 ± 0.18 |
| Epithelial necrosis | 0 | 0 | 3.6 ± 0.18 | 2.7 ± 0.42 * |
| Tubular dilatation | 0 | 0 | 1.5 ± 0.19 | 1.0 ± 0.26 |
| Epithelial cell detachment | 0 | 0 | 3.3 ± 0.25 | 2.3 ± 0.42 |
| Edema | 0 | 0 | 0 | 0 |
| Inflammation | 0 | 0 | 0.13 ± 0.13 | 0.17 ± 0.17 |
| Outer medullary casts | 0 | 0 | 4.0 ± 0 | 2.8 ± 0.48 * |
Values are presented as means ± SEM. Histopathologic scores for each item ranged from 0–4 depending on the size of the affected area: 0: < 1%, 1: 1–5%, 2: 5–25%, 3: 25–50% and 4: 50–100%. Evaluation was done by co-author SK, who is a board certified pathologist. Comparison of IR and IR+UNx group means was performed as a post-hoc analysis using Student's t-test.
*, P < 0.05 compared with IR.
UNx, unilateral nephrectomy; IR, ischemia-reperfusion. Number of animals: sham, UNx and IR groups (n = 8), IR+UNx (n = 6).