Fig 6. Oral UOX decreased SUA (A), BUN (B) and Cr (C) (mean ± SD, n = 10).

Rats in model group were gavaged with Mixture A of 10 ml/kg in the morning and with Mixture B of 5 ml/kg in the afternoon. Rats in UOX group were gavaged with Mixture A of 10 ml/kg in the morning and with Mixture B of 5 ml/kg of the same volume but added UOX of 4 u/ml in the afternoon. Rats in normal group were gavaged with normal saline of the same volume both in the morning and the afternoon. Administration was taken for 5 days. Mixture A containing adenine (15 mg/ml), potassium oxonate (15 mg/ml), omeprazole (0.4 mg/ml) and CMC-Na (0.5%); Mixture B containing NaHCO₃ (12 mg/ml) and horse serum (50%); * P < 0.05, UOX group vs model group; SUA, serum uric acid; BUN, blood urea nitrogen; Cr, blood creatinine.