. 2017 Dec 21;12(12):e0190194. doi: 10.1371/journal.pone.0190194

Table 3. Genes associated with uric acid transport or metabolism expressed in intestinal tissues (mean, n = 3).

No.	Gene	FPKM^a			P	Fold (b/c)	log2 Fold	Alias	Note^*
No.	Gene	upper^b	lower^c	kidney	P	Fold (b/c)	log2 Fold	Alias	Note^*
1	Abcg2^d	91.47	222.85	71.19	0.000	0.41	-1.28	BCRP1	secretion
2	Abcc4	1.21	2.39	17.17	0.000	0.51	-0.98	MRP4	secretion
3	Lgals9	491.29	354.93	13.62	0.039	1.38	0.47	UAT	secretion
4	Slc17a1	0.05	0.00	44.01	1.000	N/A	N/A	NPT1	secretion
5	Slc22a6	0.00	0.01	541.93	1.000	0.00	N/A	OA1	secretion
6	Slc2a9	19.37	23.98	7.21	0.078	0.81	-0.31	GLUT9	reabsorption
7	Slc2a6	1.87	1.49	1.03	0.608	1.26	0.33	GLUT9	reabsorption
8	Slc22a13	0.03	0.02	11.67	1.000	1.50	0.58	OAT10	reabsorption
9	Slc22a8	0.01	0.02	395.78	1.000	0.50	-1.00	OAT3	reabsorption
10	Slc22a12	0.00	0.00	396.99	1.000	N/A	N/A	URAT1	reabsorption
11	Xdh	295.02	78.69	35.45	0.000	3.75	1.91	XOR	synthesis
12	Uox	0.01	0.06	0.03	1.000	0.17	-2.58	UOX	degradation
13	Dad	1461.85	230.33	9.59	0.004	6.35	2.67	DAD	synthesis

* The notes of the former 10 was based on the known information from kidney; N/A, the value was incalculable; FPKM, Fragment Per Kilobases of exon model per Million mapped reads.

^amean of FPKM, raw data can be seen in S1 table.

^bDuodenum.

^cSegment 18, the end of ileum.

^dThe down-regulation of ABCG2 which secretes urate in the upper intestinal tissue is unsuitable to explain the high level of uric acid in the upper intestinal juice.