Table 4.
Association between serum bilirubin concentration and amputation in the DF group.
| Variables | Non-amputation (N=446) | Amputation (N=132) | P1 | P2 | OR (95%CI) |
|---|---|---|---|---|---|
| T-BIL (μmol/L) | 9 (7–12) | 8 (5–10) | <0.001* | 0.009*d | 0.910 (0.847–0.977) |
| By tertiles | 0.044* | ||||
| T1 (<7 μmol/L) | 168 (37.7%) | 59 (44.7%) | 0.794a | 1 (ref) | 1 (ref) |
| T2 (7–10 μmol/L) | 127 (28.5%) | 43 (32.6%) | 0.044b | 0.783 | 1.045 (0.573–1.903) |
| T3 (>10 μmol/L) | 151 (33.8%) | 30 (22.7%) | 0.017*c | 0.025* | 0.474 (0.243–0.921) |
| I-BIL | 5 (4–7) | 4 (3–6) | <0.001* | 0.233e | 0.89 (0.711–1.113) |
| By tertiles | <0.001* | ||||
| T1 (<4 μmol/L) | 159 (35.6%) | 67 (50.8%) | 0.259a | 1 (ref) | 1 (ref) |
| T2 (4–6 μmol/L) | 126 (28.3%) | 42 (31.8%) | 0.003*b | 0.794 | 1.09 (0.569–2.088) |
| T3 (>6 μmol/L) | 161 (36.1%) | 23 (17.4%) | <0.001*c | 0.157 | 0.559 (0.25–1.25) |
P1 – calculate by Mann-Whitney U test or χ2 test;
a
– T1 compare with T2;
b
– T2 compare with T3;
c
– T3 compare with T1;
P2 – calculate by binary logistic regression;
d
– adjusted for age, sex, duration of DF, BMI, WBC, ALT, AST, GGT, UA, TC, TG, HDL, LDL, HbA1C, HR, hypertension, hyperlipidemia and macrovascular complication;
e
– adjusted the variable in d and D-BIL.
*
P<0.05 in regression or P is lower than adjusted P value in the pairwise comparison by Bonferroni correction.