Figure 1.

GL-V9 treatment reduced the occurrence of inflammation-driven colon tumorigenesis. (A) Schematic of the AOM/DSS model of colitis-associated colon cancer. Percent survival (d, days) (B) Percent weight change (C), Area under the percent weight change curve (D) and macroscopic appearances of colon (E) in AOM/DSS-treated mice following treatment of GL-V9. Mock mice received a single i.p. injection of AOM and were given regular drinking water instead of DSS. Tumor numbers (F), tumor sizes (G) and tumor load (H) was determined after mice sacrificed. (I) The length of colons from each group of mice were measured. (J) H&E stains of serial sections of colons. Data are presented as mean ± SD. ^**P < 0.01 compared with AOM/mock group; ^#P < 0.05, ^##P < 0.01 compared with AOM/DSS group.