Table 1b.
Patient | Time of relapse | Site(s) of relapse | Treatment | Treatment duration | Response | RFS from start of treatment* (months) | RFS from end of treatment* (months) |
---|---|---|---|---|---|---|---|
A | 1 mo after last vaccine | Lung, spleen | Ipilimumab + nivolumab | 14 months | CR | 44 | 30 |
8.3 mo from resection | |||||||
B | 1 mo after last vaccine | Liver, spleen | Ipilimumab + nivolumab | 4 months | CR | 43 | 39.3 |
7.4 mo from resection | |||||||
C | 1 mo after last vaccine | Bone | Multiple including ipilimumab & pembrolizumab | 16 months total | POD | NA | NA |
5.2 mo from resection | |||||||
D | On study after 3rd vaccine | Skin, CNS | Lirilumab + nivolumab | One dose | CR | 40.2 | 40.2 |
4 mo from resection |
CR = complete response; EOS = end of study; F/u = follow-up; NA = not applicable; NED = no evidence of disease; POD = progression of disease; RFS = recurrence-free survival
cutoff date 07/01/2017, approximately 31 months from the end of the study