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Comparison of significant voxels detected for FA (marked by magenta dots) and MD (marked by cyan dots) using iSPREAD (Row B & C. Second column) and SPREAD (Row B & C. Third volume) analysis of longitudinal data during disease progression for patient 2. This patient had a lesion in the periventricular white matter near the temporal parietal area, which shows enhancement on the post contrast T1 image (Row A) 24 months after the baseline.
