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. 2017 Aug 24;8(62):104877–104893. doi: 10.18632/oncotarget.20501

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Copyright: © 2017 Mahbub et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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Effect of methotrexate, 6-mercaptopurine and 5-fluorouracil alone on ATP levels (A, B & C) and caspase 3 activity (D, E & F) in two lymphoid (CCRF-CEM and Jurkat), two myeloid (THP-1 and KG-1a) leukemia cell lines, and two non-tumor control cells (CD133⁺ HSC and CD34⁺ HSC). The lowest significant doses (LSD): which caused a significant reduction on ATP levels and induction of caspase 3 activity when compared to the vehicle control were determined for each anti-metabolite agent in each cell lines. The ^* indicated for LSD in each cell line.