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. 2017 Oct 19;8(62):105184–105195. doi: 10.18632/oncotarget.21917

Figure 1. Low visceral fat percentage is associated with better disease-specific survival and enrichment of immune and inflammation related gene sets in endometrial tumors.

Figure 1

Abdominal CT scans with segmentation of subcutaneous and visceral fat compartments in two patients with comparable BMI measurements, but with different visceral fat percentage (VAV%): (A) Patient with BMI 29 and low visceral fat percentage (VAV%=21%). (B) Patient with BMI 30 and high visceral fat percentage (VAV%=62%). (C) Kaplan-Meier curve showing significantly reduced disease-specific survival in patients with high VAV% (median cut-off: ≥37%; p=0.005, log-rank test). (D) Gene set enrichment analysis of tumors with low (<37%, n=56) versus high (≥37%, n=49) VAV% was performed. Diagram shows the percentage of Hallmark and Gene ontology (GO) gene sets enriched in tumors with low VAV% that were linked to immunogenic and inflammatory pathways versus other pathways. Cut-off for selected gene sets was False Discovery Rate (FDR) <5%. A full description of the gene sets is supplied in Supplementary Table 2.