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. 2017 Oct 31;8(62):105340–105355. doi: 10.18632/oncotarget.22186

Figure 9. The effects of sorafenib on biochemical parameters in rats induced to develop HCC using DEN.

Figure 9

(A) Effects of sorafenib on liver enzyme levels, total bilirubin, and albumin. While sorafenib inhibited the upregulation of ALT and AST, no effect was observed on the levels of TBIL and ALB when compared with rats treated with DEN alone. (B) Effects of sorafenib on PDGF and VEGF levels. No effect was observed on the expression levels of PDGF and VEGF when compared with rats treated with DEN alone. (C) Effect of sorafenib on agrin levels. Treatment with sorafenib significantly reduced agrin levels when compared with rats treated with DEN alone.