Table 2. Correlation between comorbidities and the risk of developing glaucoma among asthma children.
| No. of patients | No. of person-years | No. of patients with glaucoma | Incident rate (per 100,000 person-years) | Crude HR (95%CI) | Multivariate-adjusted HR* (95% CI) | |
|---|---|---|---|---|---|---|
| Age group | ||||||
| ∼≤3.12 y | 2684 | 32315.49 | 29 | 89.74 | 1.00 | 1.00 |
| >3.12 y | 2696 | 32105.40 | 59 | 183.77 | 2.07 (1.33∼3.23)* | 2.09 (1.34∼3.27)* |
| Gender | ||||||
| Female | 2071 | 24689.38 | 41 | 166.06 | 1.00 | 1.00 |
| Male | 3309 | 39731.51 | 47 | 118.29 | 0.71 (0.47∼1.08) | 0.73 (0.48∼1.11) |
| Income (NTD) | ||||||
| <15840 | 5298 | 63371.18 | 87 | 137.29 | 1.00 | 1.00 |
| ≥15840∼<21900 | 62 | 790.44 | 1 | 126.51 | 0.88 (0.12∼6.32) | 0.58 (0.08∼4.19) |
| ≥21900 | 20 | 259.27 | 0 | 0.00 | -- | -- |
| ICS use | ||||||
| No ICS use | 4148 | 49696.16 | 76 | 152.93 | 1.00 | 1.00 |
| Any ICS use | 1232 | 14724.73 | 12 | 81.50 | 0.54 (0.29∼0.98)* | 0.52 (0.28∼0.96)* |
| Medical disease | ||||||
| Prematurity | ||||||
| Without Prematurity | 5351 | 64082.85 | 88 | 137.32 | 1.00 | 1.00 |
| With Prematurity | 29 | 338.03 | 0 | 0.00 | -- | -- |
| Myopia | ||||||
| Without Myopia | 2329 | 27819.58 | 33 | 118.62 | 1.00 | 1.00 |
| With Myopia | 3051 | 36601.3 | 55 | 150.27 | 1.27 (0.82∼1.95) | 1.20 (0.78∼1.85) |
| Cataract | ||||||
| Without Cataract | 5356 | 64146 | 85 | 132.51 | 1.00 | 1.00 |
| With Cataract | 24 | 274.88 | 3 | 1091.39 | 8.18 (2.59∼25.87)* | 8.22 (2.59∼26.12)* |
| Diabetes | ||||||
| Without Diabetes | 5333 | 63835.12 | 87 | 136.29 | 1.00 | 1.00 |
| With Diabetes | 47 | 585.76 | 1 | 170.72 | 1.23 (0.17∼8.82) | 1.28 (0.18∼9.17) |
a) CI, confidence interval; HR, hazard ratio; ICS, inhaled corticosteroids; NTD, New Taiwan Dollars.
b) *p<0.05.