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. 2017 Nov 6;8(62):105525–105535. doi: 10.18632/oncotarget.22314

Figure 4. Expression of microRNA-19a silences SphK2 and inhibits OS cell growth.

Figure 4

miR-19a-3p putatively targets the 3′ UTR of SphK2 mRNA (A). Expression of miR-19a-3p (B) and SphK2 (protein and mRNA, C), as well as the relative SphK2 mRNA 3′-UTR luciferase activity (D) in the stable USO2 cells with miR-19a-mimic (three lines, “L1-L3”) or miR-control (“miR-C”), and in the parental control cells (“Par”) were shown; Cells were also subjected to the cell counting assay (E) and the listed apoptosis assays (F and G). Data were shown as mean (n=5) ± standard deviation (SD). *p<0.05 vs. “Par” cells. Experiments in this figure were repeated three times, and similar results were obtained.