Figure 6. Silence of SphK2 inhibits U2OS tumor growth in nude mice.

Parental U2OS cells (“Par”), as well as cells stably expressing SphK2-shRNA (“L1”) or miR-19a-3p (“L1”), were injected s.c. to the nude mice; Estimated tumor volume (A) and mice body weight (deducting tumor weight, C) were recorded weekly for total six weeks. At the end of experiment (week-7), tumors of the each group were isolated and weighted (B), expression of listed proteins in tumor lysates was shown (Two sets, D). ^*p<0.05 vs. “Par” tumors.