Table 5. Baseline characteristics and clinical outcomes in aspirin non-responders.
| Variable | Antiplatelet Therapy Modification | P value | |
|---|---|---|---|
| Yes (n = 154) | No (n = 69) | ||
| Age (years) | 70.9 ± 11.9 | 70.4 ± 10.8 | 0.76 |
| Men (n, %) | 70 (45.5) | 37 (53.6) | 0.27 |
| Diabetes mellitus (n, %) | 54 (35.4) | 25 (36.2) | 0.91 |
| Hypertension (n, %) | 116 (75.3) | 50 (72.5) | 0.67 |
| Current smoking (n, %) | 46 (29.9) | 17 (24.6) | 0.43 |
| Previous MI (n, %) | 4 (2.6) | 2 (2.9) | 0.99 |
| NIHSS score at enrollment | 5.8 ± 2.3 | 5.9 ± 2.1 | 0.65 |
| Hyperlipidemia (n, %) | 127 (82.5) | 61 (88.4) | 0.26 |
| Fasting glucose (mmol/L) | 7.1 ± 2.2 | 7.3 ± 2.4 | 0.56 |
| Platelet count (×109/L) | 189.2 ± 25.8 | 195.2 ± 29.2 | 0.14 |
| Stroke subtype Atherothrombotic (n, %) Small artery disease (n, %) |
95 (61.7) 59 (38.3) |
44 (63.8) 25 (36.2) |
0.78 0.78 |
| Ischemic events (n, %) | 28 (18.2) | 23 (33.3) | 0.02 |
| Ischemic stroke (n, %) | 18 (11.7) | 17 (24.6) | 0.008 |
| Transient ischemic attack (n, %) | 6 (3.9) | 3 (4.3) | 0.92 |
| MI (n, %) | 4 (2.6) | 3 (4.3) | 0.48 |
| Any bleeding event | 15 (9.7) | 6 (8.7) | 0.81 |
| GUSTO minor (n, %) | 9 (5.8) | 4 (5.8) | 0.99 |
| GUSTO moderate (n, %) | 4 (2.6) | 1 (1.4) | 0.64 |
| GUSTO severe (n, %) Gastrointestinal bleeding (n, %) Intracerebral hemorrhage (n, %) |
2 (1.3) 9 (5.8) 1 (0.6) |
1 (1.4) 3 (4.3) 1 (1.4) |
0.99 0.99 0.52 |
| Death (n, %) | 4 (2.6) | 3 (4.3) | 0.67 |
MI, myocardial infarction; NIHSS, National Institutes of Health Stroke Scale; GUSTO, Global Use of Strategies to Open Occluded Coronary Arteries.