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. 2017 Nov 6;8(63):106270–106282. doi: 10.18632/oncotarget.22286

Figure 2. miR-34a effect on the drug-resistance changes of MDR-MCF-7 cells.

Figure 2

(A) miR-34a mimics increase the proportion of cells in mitosis (G2/M phase) and decreased the proportion of MDR-MCF-7 cells in G0/G1 phase compared with NC-RNA mimics. (B) miR-34a mimics enhance the apoptotic rate of MDR-MCF-7 cells compared with NC-RNA mimics. (C–D) The representative flow cytometry figures were also shown. (E) miR-34a decrease the expression of MDR1 protein in MDR-MCF-7 compared with NC-RNA. (F) The expression of miR-34a was not change in MDR-MCF-7 cells after knocking down MDR1. Bars indicate the mean ± SD from at least three independent experiments. *P < 0.05, as compared with the NC control.