Table 3. Multivariate analysis of factors related to overall survival.

Variable	HR	95% CI	P value
AnxA2 score > 1.29	4.42	(1.84, 10.63)	0.001
Age > 60 years	0.94	(0.45, 1.96)	0.88
Female gender	1.89	(0.61. 5.89)	0.27
Tumor size > 3 cm	0.62	(0.18, 2.16)	0.46
Node positive	2.14	(0.69, 6.69)	0.19
Margin positive	0.96	(0.38, 2.44)	0.94
Grade ≥ 3	1.05	(0.52, 2.15)	0.88
Nodes ≥ 3	0.76	(0.33, 1.77)	0.52
Perineural invasion	0.53	(0.17, 1.70)	0.29
Vascular invasion	1.73	(0.78, 3.85)	0.18

Multivariate Cox modelling showing that clinical characteristics, excluding high stromal AnxA2 expression, do not affect OS. HR: hazard ratio, CI: confidence interval.