Table 2. Univariable and multivariable model for OS.
| Variable | Univariable HR (95% CI) |
P-value | Multivariable HR (95% CI) |
P-value |
|---|---|---|---|---|
| WHO PS | 1.57 (1.16–2.13) | 0.004 | 1.49 (1.04–2.13) | 0.028 (1 vs 0) |
| Time since last therapy (>6 mths) | 0.59 (0.44–0.79) | <0.001 | ||
| Neutropenia (Gr.3/4) | 0.67 (0.50–0.90) | 0.007 | ||
| Hb (mmol/L) | 0.57 (0.49–0.67) | <0.001 | 0.73 (0.61–0.87) | 0.001 |
| PSA (log, g/L) | 1.12 (1.01–1.26) | 0.040 | ||
| AP (log, U/L) | 1.83 (1.49–2.25) | <0.001 | 1.50 (1.18–1.19) | 0.001 |
| LDH (log, U/L) | 2.37 (1.73–3.25) | <0.001 | ||
| Albumin (g/L) | 0.91 (0.89–0.94) | <0.001 | 0.92 (0.89–0.95) | <0.001 |
Univariable N = 206–224 (because of missing values the number of included patients can differ per variable) Multivariable N = 200.
Abbreviations: WHO PS = world health organization performance status, Hb = hemoglobin, PSA = prostate specific antigen, AP = alkaline phosphatase, LDH = lactate dehydrogenase, log = log transformed variables when data were not normally distributed.