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. 2017 Jul 4;8(63):106486–106498. doi: 10.18632/oncotarget.18984

Figure 7.

Figure 7

(A) Combination treatment with BEZ235 and RAD001 significantly induced growth inhibition of SCLC xenograft. H526 xenografts were treated by DMSO control, 2.5 mg/kg BEZ235, 2.5 mg/kg RAD001, and the combination of BEZ235 (2.5 mg/kg) and RAD001 (2.5 mg/kg) every three days. The arrows show the days of the treatment. The mean tumor size ± SEM is shown (**P < 0.01 by an unpaired t test). (B) Imaging of representative tumors from each group. The tumors were excised at the end of the experiment. (C) H&E staining. (D) Immunohistochemical detection of Ki67. (E) Body weights of the mice during the course of treatment. The mean body weight ± SEM is shown. The numbers represent the percentage of body weight loss in the combination group compared with control group.