Table 3. Combination index (CI) of BEZ235 and RAD001 in SCLC cell lines.

Cell lines	BEZ235 dose D1 (nM)	RAD001 dose D2 (nM)	Growth inhibition x (%)	Dose of BEZ235 alone with same inhibition (Dx)1 (nM)	Dose of RAD001 alone with same inhibition (Dx)2 (nM)	CI
H82	10	10	55.3	107.2	19054.6	0.09**
H526	10	10	43.4	213.8	14454.4	0.05**
DMS79	10	10	34.7	100.0	11749.0	0.10*
H69	10	10	51.5	75.9	50118.7	0.13*
H1963	10	10	39.9	151.4	7244.4	0.07**
H196	10	10	52.9	323.6	21877.6	0.03**
H446	10	10	96.7	10000.0	10000.0	< 0.01**

^**Very strong synergism, ^*Strong synergism.