. 2017 Oct 30;8(63):106935–106947. doi: 10.18632/oncotarget.22149

Table 1. Correlations between expression of ezrin and clinicopathological features in CRC.

Cohort 1: protein analysis^a	N	Ezrin protein expression^b		P value	Cohort 2: mRNA analysis^c	N	Ezrin mRNA expression^b		P value
Variables	N	high (N = 112)	low (N = 83)	P value	Variables	N	high (N = 30)	low (N = 140)	P value
Age (years)					Age (years)
<67	83	44	39	0.432	<67	72	17	55	0.0804
≥67	112	53	59	0.432	≥67	98	13	85	0.0804
Sex					Sex
male	113	68	45	0.3635	male	99	15	84	0.3135
female	82	44	38	0.3635	female	71	15	56	0.3135
Histology					Histology
undifferentiated	15	13	2	0.0158^d	undifferentiated	13	5	8	0.0405
differentiated	176	96	80	0.0158^d	differentiated	157	25	132	0.0405
Tumor size (mm)					Tumor size (mm)
<41	83	53	30	0.1186	<45	90	29	61	0.1661
≥41	112	59	53	0.1186	≥45	80	34	46	0.1661
T classification					T classification
Tis, T1, T2	70	36	34	0.2042	Tis, T1, T2	48	9	39	0.813
T3, T4	125	76	49	0.2042	T3, T4	122	21	101	0.813
Lymph node metastasis					Lymph node metastasis
present	82	56	26	0.009	present	63	16	47	0.042
absent	113	56	57	0.009	absent	107	14	93	0.042
Lymphatic invasion					Lymphatic invasion
present	140	82	58	0.6089	present	149	26	123	0.8573
absent	55	30	25	0.6089	absent	21	4	17	0.8573
Venous invasion					Venous invasion
present	67	40	27	0.6434	present	133	24	109	0.7963
absent	128	72	56	0.6434	absent	37	6	31	0.7963
Hepatic metastasis					Hepatic metastasis
present	20	18	2	0.0019	present	26	7	19	0.1776
absent	175	94	81	0.0019	absent	144	23	121	0.1776
Peritoneal metastasis					Peritoneal metastasis
present	16	14	2	0.0111	present	4	0	4	0.3488
absent	179	98	81	0.0111	absent	166	30	136	0.3488
Distant metastasis					Distant metastasis
present	25	23	2	0.0002	present	20	7	13	0.0302
absent	170	89	81	0.0002	absent	150	23	127	0.0302
Stage					Stage
I	48	22	26	<0.0001	I	41	6	35	0.1698
II	56	27	29		II	51	5	46
III	53	28	25		III	40	9	31
IV	38	35	3		IV	38	10	28

^aFor Cohort 1 protein analysis, the average patient age and tumor size was 66.7 years and 40.8 mm, respectively.

^bThe cut-off values for high/low ezrin expression were 2.0 for protein and 0.71for mRNA.

^cFor Cohort 2 mRNA analysis, the average patient age and tumor size was 67.3 years and 44.6mm, respectively.

^dStatistically significant associations are shown in bold (P < 0.05).