Table 2. The signaling pathway was analyzed using the KEGG database for genes whose expression decreased more than 50% by NRF2-silencing in SKOV3 cells.
| Rank | KEGG number | Related pathway (number of genes) |
|---|---|---|
| 1 | hsa01100 | Metabolic pathways (40) |
| 2 | hsa05200 | Pathways in cancer (20) |
| 3 | hsa04510 | Focal adhesion (15) |
| 3 | hsa04151 | PI3K-AKT signaling pathway (15) |
| 5 | hsa04360 | Axon guidance (14) |
| 6 | hsa04810 | Regulation of actin cytoskeleton (13) |
| 6 | hsa04060 | Cytokine-cytokine receptor interaction (13) |
| 8 | hsa04010 | MAPK signaling pathway (11) |
| 8 | hsa04014 | Ras signaling pathway (11) |
| 10 | hsa04514 | Cell adhesion molecules (10) |
The signaling pathways are indicated in order of the number of genes involved. The number of genes that are associated with each signaling pathway is shown in parentheses.