Table 5. Summary of miRNAs with altered expression, their potential targets and pathways entered this study.
| miRNA | Reference | Expression | Potential target | Pathway |
|---|---|---|---|---|
| 9 | 5–7 | Up | GALNT4 | None |
| 21 | 2, 19–25, 197–200 | Up | None | None |
| 22 | 4, 26, 27 | Down | YWHAZ, HDAC4 | Cell invasion, migration, proliferation, tumourigenicity and YWHAZ/AKT1/foxo3a signaling |
| 29a | 9, 37, 38, 200, 202 | Up | None | None |
| 29c | 38, 40, 41 | Down | SIRT1 | None |
| 34a | 47–50 | Down | FOXM1, MYC, BCL2, AXL | Cell apoptosis, chemoresistance, proliferation, viability and FOXM1/MYC signaling |
| 34c | 50–52 | Down | NCKAP1 | Cell cycle, growth, invasion and proliferation |
| 122 | 195, 198, 205–208 | None | None | None |
| 148a | 87-89, 208, 211 | Down | USP4, SIP1 | Cell invasion, migration and proliferation |
| 155 | 9, 98–100 | Up | ARID2, FBXW7 | Cell apoptosis, cycle, invasion, proliferation and tumorigenesis |
| 192 | 202, 208 | Up | None | None |
| 199a | 11, 113, 114 | Down | HIF1A, VEGFA, IGF1, IGF2 | Cell growth, invasion, proliferation and Warburg effect |
| 200a | 116-118 | Down | MACC1, CDK6, ZEB2 | Cell cycle, growth, metastasis and proliferation |
| 203 | 119–121 | Down | ADAM9, HULC | Cell apoptosis, invasion and proliferation |
| 221 | 20, 132–135 | Up | Bmf | Cell apoptosis and growth |
| 224 | 198, 218 | None | None | None |
GALNT4: polypeptide N-acetylgalacosaminyltransferase 4; YWHAZ: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; HDAC4: histone deacetylase 4; AKT1: AKT serine/threonine kinase 1; foxo3a: forkhead box O3A; SIRT1: sirtuin 1; FOXM1: forkhead box M1; MYC: MYC proto-oncogene, bHLH transcription factor; BCL2: BCL2, apoptosis regulator; AXL: AXL receptor tyrosine kinase; NCKAP1: NCK associated protein 1; USP4: ubiquitin specific peptidase 4; SIP1: Sip1p; ARID2: AT-rich interaction domain 2; FBXW7: F-box and WD repeat domain containing 7; HIF1A: hypoxia inducible factor 1 alpha subunit; VEGFA: vascular endothelial growth factor A; IGF1: insulin like growth factor 1; IGF2: insulin like growth factor 2; MACC1: MACC1, MET transcriptional regulator; CDK6: cyclin dependent kinase 6; ZEB2: zinc finger E-box binding homeobox 2; ADAM9: ADAM metallopeptidase domain 9; HULC: hepatocellular carcinoma up-regulated long non-coding RNA; BMF: Bcl2 modifying factor.