. 2017 Sep 18;8(63):107334–107345. doi: 10.18632/oncotarget.21015

Table 1. PAR-1 activators.

PAR-1	Activators	The activation point
	Thrombin [3–7, 13]	R^41-S⁴², S^42-FLLRN⁴⁷
	MMP-1,MMP-2,MMp-9,MMP-13 [3, 25]	D^39-P⁴⁰
	APC [26], Plasmin [26], Factor Xa [26], Granzyme A [26], Gingipains-R [26],	Cleave the N-terminus, with the EPCR as a cofactor
	TF-FVIIa [27]	Gene elcited by TF-FVIIa through PAR-2