Table 1: Independent Predictors of Post-discharge Mortality in Registries.

Registry	Year of publication	Sample size	Prediction period	Independent predictor results from multivariate analysis
OPTIMIZE-HF[9]	2008	4400	60-day mortality	Creatinine; sodium; age; HR; liver disease; previous CVA/TIA; peripheral vascular disease; race; left ventricular systolic dysfunction; COPD; SBP; previous HF hospitalisation
EFICA[11]	2006	599	1-month and 12-month mortality	Shock; renal dysfunction; ischaemia; liver dysfunction; previous ADHF episode; comorbidity; SBP; pulmonary oedema
MOCA[12]12	2013	5306	1-month and 12-month mortality	Age; sex; SBP and DBP; eGFR; sodium; haemoglobin; heart rate; NT-proBNP; CRP; MR-proADM; sST2
FINN AKVA[13]	2006	620		age, male gender; lower systolic blood pressure (SBP) on admission; C-reactive protein and serum creatinine >120 mmol/L
ESC-HF-LT registry[14]	2016	5039	1-year mortality	Age; SBP; EF; NYHA III–IV; congestion; aortic stenosis; diabetes; COPD; previous stroke; renal dysfunction; hepatic dysfunction
AHEAD[15]	2011	3438	1-year mortality	Age; creatinine; valvular disease; LVEF <30 %; previous stroke or TIA; de novo vs worsening chronic HF
IN-HF[16]	2013	1855	1-year mortality	Age; low SBP; somnolent or confused; Na <136 mEq/l; creatinine >1.5 mg/dl; BUN >50 mg/dl; Hb <12 g/dl; APE; COPD

ADHF = acute decompensated heart failure; AHEAD = Acute Heart Failure Database; APE = acute pulmonary embolism; BUN = blood urea nitrogen; COPD = chronic obstructive pulmonar disease; CRP = C-reactive protein; CVA/TIA = cerebrovascular accident/transitory ischaemic accident; DBP = diastolic blood pressure; EF = ejection fraction; EFICA = Etude Francaise de l’Insuffisance Cardiaque Aigue; eGFR = estimated glomerular filtration rate; ELAN = European Collaboration on Acute Decompensated Heart Failure; ESC HF LT = European Society of Cardiology Heart Failure Long-Term Registry; FINN AKVA = Finnish Acute Heart Failure Study; Hb = haemoglobin; HF = heart failure; HR = heart rate; IN HF = Italian Network on Heart Failure; LVEF = left ventricular ejection fraction; MOCA = Multinational Observational Cohort on Acute Heart Failure; MR-proADM = mid-regional pro-adrenomedullin; NT-proBNP = N-terminal pro brain natriuretic peptide; NYHA = New York Heart Association; OPTIMIZE-HF = Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure; SBP = systolic blood pressure; sST2 = soluble suppression of tumorigenicity 2.