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. Author manuscript; available in PMC: 2018 Dec 7.
Published in final edited form as: Ann Neurol. 2017 Dec 7;82(6):951–960. doi: 10.1002/ana.25104

Figure 2. Inhibition of optogenetically-induced corticostriatal glutamate release by MSX-3, pramipexole, ropinirole and gabapentin.

Figure 2

(A–D) Effect of perfusion of the adenosine A2AR antagonist MSX-3, the dopamine receptor agonists pramipexole and ropinirole and the α2δ ligand gabapentin (1 μM in all cases) on optogenetically-induced glutamate release in the lateral striatum of BID rats (red plot) and controls (black plot); time ‘0’ represents the values of samples prior to stimulation; the period of stimulation (20 min) is represented as a train of vertical lines; results are expressed as means + S.E.M. of percentage of the average of three values before stimulation (n = 6–9 per group). *: p<0.05, as compared to value of the last sample before the stimulation, respectively (paired t test).