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. Author manuscript; available in PMC: 2018 Dec 7.
Published in final edited form as: Ann Neurol. 2017 Dec 7;82(6):951–960. doi: 10.1002/ana.25104

Figure 3. Effect D2-like receptor antagonists on pramipexole-mediated inhibition of optogenetically-induced corticostriatal glutamate release.

Figure 3

(A–C) Effect of co-perfusion of pramipexole (1 μM) with the selective D4R antagonist L745–870, the non-selective D2R-D3R antagonist raclopride or the D3R antagonist VK4–116 (10 μM in all cases) on optogenetically-induced glutamate release in the lateral striatum of BID rats (red plot) and controls (black plot); time ‘0’ represents the values of samples prior to stimulation; the period of stimulation (20 min) is represented as a train of vertical lines; results are expressed as means + S.E.M. of percentage of the average of three values before stimulation (n = 7–9 per group). *: p<0.05, as compared to value of the last sample before the stimulation, respectively (paired t test).