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. 2017 Nov 23;38(1):56–65. doi: 10.1111/opo.12425

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© 2017 The Authors. Ophthalmic and Physiological Optics published by John Wiley & Sons Ltd on behalf of College of Optometrists

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Distribution of hyperreflective structures, presumed to be activated retinal astrocytes and Müller cells (ARAM), in regions of abnormal retinal nerve fibre bundle (RNFB) reflectance. The numbers labelling the figures are the axial depths from the inner limiting membrane at which the en‐face images were generated. (a) and (b) are examples of subjects in whom the distribution of the hyperreflective structures appear to be concentrated in the region of glaucomatous RNFB reflectance abnormality. (c) and (d) show the en‐face images at deeper depths distinctly showing the spatial location of RNFB reflectance abnormalities, and circumpapillary RNFB thickness profiles for the subjects in (a) and (b) respectively.