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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Neurogastroenterol Motil. 2017 Jul 17;30(1):10.1111/nmo.13157. doi: 10.1111/nmo.13157

Figure 2.

Figure 2

Effect of nicotine (100 μM) on circular muscle contractions of rat proximal colon. A: Representative traces of circular muscle contractions showing the contractile effect of 100 μM nicotine (upper) and the inhibitory effect of FFA3 agonist MQC on nicotine-induced contractions (lower). B-C: Peak amplitude of nicotine-evoked contraction was compared in the presence or absence (Control) of TTX (1 μM), hexamethonium (Hex, 1 mM), atropine (1 μM), PTX (500 ng/ml), or various concentration of MQC or AR420626 (AR). D-E: FWHM values of nicotine-evoked peak were determined. Pretreatment with PTX reversed the inhibitory effect of AR420626 (10 μM). *P < 0.05 vs. Control and †P < 0.05 vs. AR (10 μM) by ANOVA followed by Tukey's multiple comparison test. (N = 4 - 6)