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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Neurogastroenterol Motil. 2017 Jul 17;30(1):10.1111/nmo.13157. doi: 10.1111/nmo.13157

Figure 4.

Figure 4

Effect of serotonin (5-HT) on circular muscle contractions of rat proximal colon. A: Representative traces of circular muscle contractions showing that serotonin suppressed spontaneous contractions after initial contraction (upper) and pretreatment of AR420626 inhibited the effect of serotonin (lower). B-C: Serotonin-induced peak (B) and peak time after the initial contraction (C) were determined in the presence or absence (Control) of L-NAME (0.1 mM), AR420626 (10 μM), or granisetron (10 μM). All preparations were pretreated with indomethacin. *P < 0.05 vs. Control by ANOVA followed by Dunnett's multiple comparison test. (N = 4 - 8)