Table 1. Demographic and clinical characteristics of patients treated with the levonorgestrel-releasing IUD for complex atypical hyperplasia or low grade endometrioid endometrial cancer*.
| Demographic / Pathologic factor | All Patients N = 46 |
Evaluable Patients N = 32 |
Non-Evaluable Patients N = 14 |
P-Value+ | ||||
|---|---|---|---|---|---|---|---|---|
| 95% CI | N (%) | 95% CI | N (%) | 95% CI | ||||
| Age in years (n, median, range) | N | 46 | 32 | 14 | 0.459 | |||
| Median | 47.1 | 45.6 | 53.0 | |||||
| Min-Max | 18.5 - 85.2 | 18.5 - 85.2 | 28.5 - 69.8 | |||||
| BMI in kg/m2 (n, median, range) | N | 45 | 31 | 14 | 0.961 | |||
| Median | 45 | 45 | 43.5 | |||||
| Min-Max | 19 - 74 | 20 - 74 | 19 - 70 | |||||
| Uterine Size (n, median, range) | N | 27 | 19 | 8 | 0.059 | |||
| Median | 8.9 | 8.1 | 9.7 | |||||
| Min-Max | 5.6 - 12.4 | 6.5 - 12.4 | 5.6 - 11.2 | |||||
| Race (n, %) | White | 24 (52.2%) | 36.9%-67.1 | 18 (56.3%) | 37.7%-73.6% | 6 (42.9%) | 17.7%-71.1% | 0.411 |
| Hispanic | 15 (32.6%) | 19.5%-48.0% | 10 (31.3%) | 16.1%-50.0 | 5 (35.7%) | 12.8%-64.9% | ||
| Black | 5 (10.9%) | 3.6%-23.6% | 2 (6.3%) | 0.8%-20.8% | 3 (21.4%) | 4.7%-50.8% | ||
| American Indian/Alaska Native | 2 (4.3%) | 0.5%-14.8% | 2 (6.3%) | 0.8%-20.8% | 0 (0.0%) | NE-23.2% | ||
| Parity (n, %) | Nulliparous | 25 (54.3%) | 39.0%-69.1% | 19 (59.4%) | 40.6%-76.3% | 6 (42.9%) | 17.7%-71.1% | 0.349 |
| Parous | 21 (45.7%) | 30.9%-61.0% | 13 (40.6%) | 23.7%-59.4% | 8 (57.1%) | 28.9%-82.3% | ||
| Histology (n, %) | CAH | 23 (50.0%) | 34.9%-65.1% | 15 (46.9%) | 29.1%-65.3% | 8 (57.1%) | 28.9%-82.3% | 0.103 |
| G1 Endometrioid | 15 (32.6%) | 19.5%-48.0% | 9 (28.1%) | 13.7%-46.7% | 6 (42.9%) | 17.7%-71.1% | ||
| G2 Endometrioid | 8 (17.4%) | 7.8%-31.4% | 8 (25.0%) | 11.5%-43.4% | 0 (0.0%) | NE-23.2% | ||
| Reason (n, %) | CAH | 3 (6.5%) | 1.4%-17.9% | 2 (6.3%) | 0.8%-20.8% | 1 (7.1%) | 0.2%-33.9% | 0.879 |
| Obesity | 3 (6.5%) | 1.4%-17.9% | 3 (9.4%) | 2.0%-25.0% | 0 (0.0%) | NE-23.2% | ||
| Comorbidity | 4 (8.7%) | 2.4%-20.8% | 2 (6.3%) | 0.8%-20.8% | 2 (14.3%) | 1.8%-42.8% | ||
| Obesity + Comorbidity | 20 (43.5%) | 28.9%-58.9% | 13 (40.6%) | 23.7%-59.4% | 7 (50.0%) | 23.0%-77.0% | ||
| Fertility | 9 (19.6%) | 9.4%-33.9% | 6 (18.8%) | 7.2%-36.4% | 3 (21.4%) | 4.7%-50.8% | ||
| Obesity + Fertility | 6 (13.0%) | 4.9%-26.3% | 5 (15.6%) | 5.3%-32.8% | 1 (7.1%) | 0.2%-33.9% | ||
| Patient Desire | 1 (2.2%) | 0.1%-11.5% | 1 (3.1%) | 0.1%-16.2% | 0 (0.0%) | NE-23.2% |
*
Abbreviations: IUD, intrauterine device; CAH, complex atypical hyperplasia; BMI, body mass index;
+
Mann-Whitney test for age, BMI and uterine size; Fisher's exact test for remaining variables; Tested distribution of variables between evaluable and non-evaluable participants