Table 3.
Hazard Ratios (HRs) and 95% Confidence Intervals for the association between obesity status and time to any cancer death, stratified by BMI category. Among 766 total cancer deaths, and 2971 competing all-cause deaths.
| Any Cancer Deaths
| ||||||
|---|---|---|---|---|---|---|
| Overall | (# Deaths /# At risk) | Mortality Rate1 (95% CI) | Model 12 HR (95% CI) | Model 1 Subdistribution HR (95% CI)4 | Model 23 HR (95% CI) | Model 2 Subdistribution HR (95% CI)4 |
| Normal Weight (Referent) | 256 / 5377 | 7.33 (6.49 – 8.29) | - | - | - | - |
| Overweight | 255 / 8351 | 4.58 (4.05 – 5.18) | 0.67 (0.55 – 0.81) | 0.69 (0.57 – 0.83) | 0.65 (0.54 – 0.79) | 0.67 (0.55 – 0.82) |
| Obese | 255 / 8786 | 4.48 (3.96 – 5.06) | 0.81 (0.67 – 0.98) | 0.82 (0.68 – 0.99) | 0.76 (0.61 – 0.94) | 0.78 (0.62 – 0.97) |
|
| ||||||
| Metabolically Healthy | ||||||
|
| ||||||
| Normal Weight (Referent) | 199 / 4720 | 6.45 (5.62 – 7.42) | - | - | - | - |
| Overweight | 167 / 5503 | 4.50 (3.87 – 5.24) | 0.79 (0.63 – 0.99) | 0.83 (0.66 – 1.03) | - | - |
| Obese | 71 / 2872 | 3.76 (2.98 – 4.75) | 0.89 (0.66 – 1.20) | 0.91 (0.68 – 1.22) | - | - |
|
| ||||||
| Metabolically Unhealthy | ||||||
|
| ||||||
| Normal Weight (Referent) | 57 / 657 | 13.94 (10.75 – 18.07) | - | - | - | - |
| Overweight | 88 / 2848 | 4.74 (3.85 – 5.85) | 0.39 (0.27 – 0.55) | 0.39 (0.28 – 0.56) | - | - |
| Obese | 184 / 5914 | 4.83 (4.18 – 5.58) | 0.51 (0.36 – 0.70) | 0.51 (0.36 – 0.71) | - | - |
Rate per 1,000 Person-Years
Adjusted for age, race, sex, education, income, tobacco use, alcohol use, physical inactivity, LDL cholesterol, and comorbidity score.
Adjusted for age, race, sex, education, income, tobacco use, alcohol use, physical inactivity, LDL cholesterol, comorbidity score, and metabolic health status.
Estimated using Fine & Gray method accounting for all-cause mortality as competing risk, models adjusted for age, race, sex, education, income, tobacco use, alcohol use, physical inactivity, LDL cholesterol, and comorbidity score.
Metabolically unhealthy defined as the presence of three or more metabolic components including 1) elevated fasting glucose, 2) high triglycerides, 3) dyslipidemia, 4) hypertension, and 5) high waist circumference. Normal weight: BMI 18.5 – 24.9 kg/m2; Overweight: BMI 25.0 – 29.9 kg/m2; Obese: BMI = 30 kg/m2
Bold indicates statistically significant association at 0.05 alpha level.