Table 5.
Hazard Ratiosa (HRs) and 95% confidence intervals for the association between components of metabolic health status and time to cancer death and time to obesity-relatedc cancer death stratified by BMI category.
| Obesity Status
|
||||
|---|---|---|---|---|
| All | Normal Weight (BMI 18.5 – 24.9 kg/m2) | Overweight (BMI 25.0 – 29.9 kg/m2) | Obese (BMI ≥ 30 kg/m2) | |
| Cancer Mortality | ||||
|
| ||||
| Componentsb | ||||
| High WC | 1.00 (0.86 – 1.17) | 1.21 (0.74 – 1.97) | 1.05 (0.79 – 1.39) | 1.37 (0.86 – 2.18) |
| Elevated Triglycerides | 0.95 (0.80 – 1.13) | 1.10 (0.80 – 1.52) | 1.17 (0.88 – 1.56) | 0.75 (0.55 – 1.01) |
| Reduced HDL Cholesterol | 1.20 (1.03 – 1.40) | 1.89 (1.43 – 2.49) | 0.84 (0.64 – 1.11) | 1.26 (0.97 – 1.65) |
| Elevated blood pressure | 1.14 (0.95 – 1.38) | 1.21 (0.90 – 1.62) | 1.03 (0.76 – 1.41) | 1.35 (0.89 – 2.05) |
| Elevated fasting glucose | 1.01 (0.87 – 1.18) | 1.01 (0.75 – 1.36) | 0.99 (0.76 – 1.30) | 1.14 (0.88 – 1.49) |
| Overalla | Ref | 0.67 (0.55 – 0.80) | 0.82 (0.68 – 0.99) | |
|
| ||||
| Obesity-Related Cancer Mortalityc | ||||
|
| ||||
| Componentsb | ||||
| High WC | 1.29 (0.92 – 1.79) | 0.71 (0.17 – 3.06) | 0.86 (0.45 – 1.61)3 | 4.22 (1.02 – 17.40) |
| Elevated Triglycerides | 0.87 (0.60 – 1.28) | 1.34 (0.62 – 2.88) | 0.89 (0.46 – 1.73)3 | 0.61 (0.33 – 1.10) |
| Reduced HDL Cholesterol | 1.21 (0.87 – 1.68) | 2.45 (1.25 – 4.79) | 0.70 (0.38 – 1.31)3 | 1.15 (0.70 – 1.90) |
| Elevated blood pressure | 1.32 (0.88 – 1.98) | 1.17 (0.57 – 2.37) | 1.28 (0.64 – 2.55)3 | 1.36 (0.64 – 2.89) |
| Elevated fasting glucose | 1.20 (0.87 – 1.66) | 2.00 (1.04 – 3.85) | 1.04 (0.59 – 1.83) | 0.94 (0.58 – 1.54) |
| Overalla | Ref | 0.86 (0.57 – 1.31) | 1.32 (0.87 – 2.01) | |
|
| ||||
| Cancer Mortality | ||||
|
| ||||
| # Metabolic Unhealthy Components | ||||
| 0 (Referent) | - | - | - | - |
| 1 | 1.31 (0.94 – 1.82) | 1.67 (1.08 – 2.57) | 1.07 (0.62 – 1.84) | 0.78 (0.17 – 3.56) |
| 2 | 1.28 (0.92 – 1.77) | 1.48 (0.93 – 2.36) | 1.13 (0.67 – 1.93) | 1.13 (0.27 – 4.65) |
| 3+ | 1.29 (0.95 – 1.77) | 2.31 (1.44 – 3.72) | 0.95 (0.56 – 1.62) | 1.18 (0.29 – 4.77) |
| p value for trend | 0.41 | <0.01 | 0.74 | 0.65 |
|
| ||||
| Obesity-Related Cancer Mortalityc | ||||
|
| ||||
| # Metabolic Unhealthy Components | ||||
| 0 (Referent) | - | - | - | - |
| 1 | 2.25 (0.94 – 5.40) | 1.74 (0.56 – 5.40) | 2.85 (0.66 – 12.36) | Undefined |
| 2 | 2.72 (1.15 – 6.39) | 1.92 (0.59 – 6.28) | 2.68 (0.62 – 11.62) | Undefined |
| 3+ | 2.65 (1.14 – 6.15) | 3.78 (1.16 – 12.31) | 1.41 (0.31 – 6.45) | Undefined |
| p value for trend | 0.12 | 0.10 | 0.15 | 0.46 |
766 cancer deaths
a
Models adjusted for age, sex, race, education, income, tobacco use, alcohol use, physical inactivity, and comorbidity score.
b
Referent groups for each hazard ratio is the absence of metabolic component.
c
165 obesity-related cancer deaths included: breast, colorectal, kidney, pancreatic, endometrial, and esophageal cancers.
Bold indicates statistically significant association at 0.05 alpha level.