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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2017 Nov 3;9(1):10.1002/wrna.1452. doi: 10.1002/wrna.1452

Figure 2. Design and construction of various RNA square nanostructures.

Figure 2

(a) RNA nanosquare designed and formed from five RNA oligos with pRNA-3WJ motifs at the corners25. Adapted with permission from Ref.25 © 2014 American Chemical Society. (b) RNA nanosquares designed and formed from two RNA oligos with two k-turn units at each corner (PDB: 4SC1)51. Adapted with permission from Ref.51 © 2016 The Royal Society of Chemistry. (c) RNA nanosquares designed from three-way junction formed by tetra-Us and helixes as building unit at the corner. Adapted with permission from Ref.54 © 2017 Elsevier Inc. (d) RNA nanosquares designed and formed from five RNA oligos with 3WJ motifs at each corner(PDB, 2OGM)28. Adapted with permission from Ref.28 © 2016 Elsevier. (e) Tectosqaure nanoparticles designed and formed from RA, 3WJ and tRNA motifs16. Adapted with permission from Ref.16 © 2009 American Chemical Society. (f) RNA nanosquare designed and formed from four piece of identical RNA oligos with IIa-1 motifs (PDB:3P59) at the corners62. Adapted with permission from Ref.62 © 2011 National Academy of Sciences.