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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2017 Nov 3;9(1):10.1002/wrna.1452. doi: 10.1002/wrna.1452

Figure 4. Design and construction of various 3D RNA nanostructures.

Figure 4

(a) RNA tetrahedron designed and formed by placing pRNA-3WJ at the four corners72 as shown by AFM and cryo-EM. Adapted with permission from Ref.72 © 2016 Wiley VCH Verlag GmbH and Co. KGaA, Weinheim. (b) RNA prism designed and formed by placing pRNA-3WJ at the six corners73. Small RNA molecules, such as MG aptamer can be encapsulated inside the prism. Adapted with permission from Ref.73 © 2016 Wiley VCH Verlag GmbH and Co. KGaA, Weinheim. (c–d) RNA triangular nanoprism I and tetragonal nanoprism II designed and self-assembled by re-engineered pRNA74. Adapted with permission from Ref.74 © 2014 Macmillan Publishers Limited. (e) Polyhedron made of tRNA subunits75. Adapted with permission from Ref.75 © 2010 Macmillan Publishers Limited. (f) Ten stranded RNA cube with dangling ends76. Adapted with permission from Ref.76 © 2010 Macmillan Publishers Limited. (g) Homo-octameric prism designed and formed with an RNA tile with T junction structure78. Adapted with permission from Ref.78 © 2015 Macmillan Publishers Limited. (h–i) RNA dendrimer G3 and G4 designed and formed by placing pRNA-square at the central and extended with multiple pRNA-3WJ structures27. Adapted with permission from Ref.27 © 2015 Elsevier Inc.