Figure 6. Application of multifunctional RNA nanoparticles in cancer research.
(a) pRNA-X nanoparticle labelled with Alexa647 distributed to retinal cells after subconjunctival injection79. Adapted with permission from Ref.79 © 2014 Springer International Publishing Group. (b) Folate directed delivery of 3WJ-BRCAA1 siRNA to gastric cancers. Tumor inhibition observed in a gastric cancer xenograft mice model after systemic injection46. Adapted with permission from Ref.46 © 2014 Macmillan Publishers Limited. (c) Her2 aptamer directed delivery of MED siRNA to breast cancers and effect in overcoming the tamoxifen resistance of xenograft human breast cancer43. Adapted with permission from Ref.43 © 2016 American Chemical Society. (d) Folate directed delivery of 3WJ-luciferase siRNA to glioblastoma and effect in silencing luciferase gene expression in glioblastoma mice model after systemic injection80. Adapted with permission from Ref.80 © 2015 Impact Journals, LLC. (e) EGFR aptamer directed delivery of 3WJ-anti-miR21 to breast cancer cells and effect in inhibition of cancer growth in orthotopic mice model after systemic injection24. Adapted with permission from Ref.24 © 2015 American Chemical Society. (f) PSMA aptamer directed delivery of 3WJ-anti-miR21 and 3WJ-anti-miR17 to prostate cancer cells and effect in inhibition of cancer growth in mice model after systemic injection41. Adapted with permission from Ref.41 © 2016 The American Society of Gene and Cell Therapy. (g) RNA-CpG polygons induced strong cytokine induction in vivo56. Adapted with permission from Ref.56 © 2014 Oxford University Press. (h) Annexin A2 aptamer directed delivery of 3WJ-doxorubicin to ovarian cancer cells, and its effect in targeting to ovarian cancer in mice model after systemic injection81. Adapted with permission from Ref.81 © 2017 Elsevier Inc.