Table 1.
Baseline | 6 Months | 12 Months | Group × Time |
Overall Group |
Overall Time |
6 vs. 0 | 12 vs. 6 | 12 vs. 0 | |||||||||
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N | mean±SEM | mean±SEM | mean±SEM | P-value | P-value | P-value | P-value | P-value | P-value | ||||||||
Weight (kg) | WL | 35 | 88 | ± | 3 | 80 | ± | 2 | 82 | ± | 3 | 0.98 | 0.17 | 0.000 | <0.001 | <0.001 | <0.001 |
AEX+WL | 30 | 83 | ± | 3 | 75 | ± | 2 | 77 | ± | 3 | |||||||
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BMI (kg/m2) | WL | 35 | 33.2 | ± | 0.9 | 30.3 | ± | 0.9 | 31.0 | ± | 0.9 | 0.96 | 0.23 | 0.000 | <0.001 | <0.001 | <0.001 |
AEX+WL | 30 | 31.7 | ± | 1.0 | 28.8 | ± | 0.9 | 29.4 | ± | 1.0 | |||||||
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Total body fat (%) | WL | 28 | 47.1 | ± | 0.8 | 43.8 | ± | 1.2 | 45.0 | ± | 1.1 | 0.39 | 0.61 | 0.000 | <0.001 | <0.001 | <0.001 |
AEX+WL | 23 | 47.1 | ± | 1.0 | 42.7 | ± | 1.3 | 43.8 | ± | 1.3 | |||||||
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Fat mass (kg) | WL | 28 | 41.1 | ± | 1.9 | 35.4 | ± | 2.0 | 36.4 | ± | 2.0 | 0.39 | 0.67 | 0.000 | <0.001 | <0.001 | <0.001 |
AEX+WL | 23 | 40.3 | ± | 2.1 | 33.5 | ± | 2.2 | 35.2 | ± | 2.3 | |||||||
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FFM (kg) | WL | 28 | 45.3 | ± | 1.2 | 43.8 | ± | 1.1 | 43.4 | ± | 1.2 | 0.13 | 0.78 | 0.000 | <0.001 | <0.001 | <0.001 |
AEX+WL | 23 | 44.4 | ± | 1.4 | 43.2 | ± | 1.2 | 43.5 | ± | 1.3 | |||||||
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Mid-thigh muscle area (cm2) | WL | 27 | 72.4 | ± | 2.8 | 69.9 | ± | 2.8 | 70.0 | ± | 3.0 | 0.001 | 0.38 | 0.43 | 0.08 | 0.93 | 0.20 |
AEX+WL | 20 | 71.1 | ± | 2.8 | 76.2 | ± | 2.7* | 75.7 | ± | 3.3 | <0.01 | 0.99 | <0.05 | ||||
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Mid-thigh subcutaneous fat area (cm2) | WL | 27 | 157.0 | ± | 8.9 | 131.5 | ± | 8.3 | 139.1 | ± | 8.1 | 0.54 | 0.78 | 0.000 | <0.001 | <0.001 | <0.001 |
AEX+WL | 20 | 150.2 | ± | 11.0 | 131.0 | ± | 10.1 | 135.6 | ± | 11.0 | |||||||
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Mid-thigh intramuscular fat area (cm2) | WL | 27 | 20.1 | ± | 1.5 | 19.4 | ± | 1.7 | 20.9 | ± | 1.9 | 0.12 | 0.76 | 0.56 | 0.81 | 1.0 | 1.0 |
AEX+WL | 20 | 20.1 | ± | 1.4 | 19.6 | ± | 1.5 | 18.6 | ± | 1.5 | |||||||
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RMR (kcal/d) | WL | 21 | 1472 | ± | 53 | 1388 | ± | 59 | 1446 | ± | 52 | 0.94 | 0.75 | 0.03 | <0.01 | <0.05 | 0.41 |
AEX+WL | 17 | 1447 | ± | 59 | 1355 | ± | 66 | 1433 | ± | 57 | |||||||
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VO2max (L/min) | WL | 12 | 1.52 | ± | 0.10 | 1.44 | ± | 0.06 | 1.38 | ± | 0.07 | 0.04 | 0.02 | 0.02 | 0.14 | 0.29 | 0.09 |
AEX+WL | 17 | 1.80 | ± | 0.11* | 1.95 | ± | 0.15† | 1.65 | ± | 0.08* | <0.05 | <0.01 | <0.05 |
P<0.05,
P<0.001,
AEX+WL vs WL