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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Am J Transplant. 2017 Sep 8;18(1):74–88. doi: 10.1111/ajt.14434

Figure 6. T cell subset composition in tissues varies more by age and less by clinical factors.

Figure 6

(A) CD4+ and CD8+ T cell subsets are defined as a function of CD45RA and CCR7: Terminal Effector (TEMRA: CD45RA+CCR7−), Naïve (CD45RA+CCR7+), and Effector Memory (TEM: CD45RA−CCR7−). (B) Compiled subset results for CD4+ T cells showing naive (upper) and TEM (lower) percentages (mean ± SEM) in blood and 9 tissue sites (n=82). (C) Compiled subset results for CD8+ T cells showing naive (upper), TEM (middle) and TEMRA (lower) percentages (mean ± SEM) in blood and 9 tissue sites (n=82). (D) Matrix of significant association (p<0.05) of T cell subset frequencies with eight clinical parameters without adjustments for age (top), and adjusted for age as a covariate (bottom), as defined in Figure 1C. The matrix grid shows an ANOVA analysis analyzing the presence/absence of each factor in each tissue. Shaded pink boxes indicating significant (p<0.05) positive correlation with the factor and shaded blue boxes indicating negative correlation with the factor. In the age-adjusted analysis, HT as a COD was associated with significantly higher CD4+ naïve cells (p<0.001) and CD8+ naïve cells (p=0.002) in the LLN compared to donors who died of a stroke.