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. 2017 Dec 21;7:18000. doi: 10.1038/s41598-017-18177-1

Figure 3.

Figure 3

HPV16 neutralization titers elicited by the nanoparticulate PfTrx-L2-OVX313 antigen formulated with different immune-adjuvants. HPV16 L1-PBNA data obtained with immune-sera from mice (10 animals/group) immunized with the PfTrx-L2-OVX313 antigen formulated with the indicated adjuvants (see ‘Methods’ for details on the immunization protocol). The results of three parallel sets of immunizations performed with the reference PfTrx-L2 and with the nanoparticulate PfTrx-L2-OVX313 antigen are shown on the left-hand and the right-hand side respectively. Dots represent neutralization titers measured in individual vaccinated animals; the geometric means of the titers for each group are indicated by horizontal lines. Statistical significance (p-values) of the differences between the immune-responses measured in the different treatment groups is indicated.