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. 2017 Dec 21;7:18000. doi: 10.1038/s41598-017-18177-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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L1-PBNA neutralization titers against different HPV types elicited by immunization with the monoepitope and the multiepitope antigens. The results of L1-PBNAs conducted against the indicated HPV types with sera from mice (10 animals/group) immunized with the HPV 16 monoepitope (PfTrx-L2-OVX313) and the multiepitope (PfTrx-L2(8x)-OVX313) antigens adjuvanted with AddaVax^TM (50% v/v) are shown in each panel. L1-PBNA data presentation and analysis are as specified in Fig. 3 legend.