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. 2017 Dec 21;8:2249. doi: 10.1038/s41467-017-02353-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — DEK expression correlates with CELF1 expression in vivo. a Single-cell quantification analysis of CELF1 (red) and DEK (green) protein expression by confocal microscopy in a representative skin metastasis of human melanoma. Images on the right show higher magnification of selected areas of the lesion with high or low expression of both proteins (insets 1 and 2, respectively). b Quantification of nuclear staining of CELF1 and DEK in skin and lymph node melanoma metastasis human biopsies, respectively. Relative nuclear staining of CELF1 and DEK plotted in a maximum range of RGB color scale (0–255). Data points were pseudo-colored based on red/green signal intensity ratio (red, ratio≥2; green, ratio≤0.5; yellow, 0.5 < ratio <2). r, Pearson correlation; n, total number of quantified cells in the whole tissue. c DEK vs. CELF1 mRNA expression in various cancer types plotted as a function of corresponding significance (Pearson correlation value) ADC adrenocortical carcinoma, AML acute myeloid leukemia, BIC breast invasive carcinoma, BLGG brain lower grade glioma, BLUC bladder urothelial carcinoma, ChAC cholangiocarcinoma, COAC colorectal adenocarcinoma, CSCC cervical squamous cell carcinoma and endocervical adenocarcinoma, ESCA esophageal carcinoma, GLIO-MF glioblastoma multiforme, HNSCC head and neck squamous cell carcinoma, KICH kidney chromophobe, KRCCC kidney renal clear cell carcinoma, KRPCC kidney renal papillary cell carcinoma, LIHC liver hepatocellular carcinoma, LNDLBCL lymphoid neoplasm diffuse large B-cell lymphoma, LSCC lung squamous cell carcinoma, LUAD lung adenocarcinoma, Meso mesothelioma, OSC ovarian serous cystadenocarcinoma, PAAD pancreatic adenocarcinoma, PhPa pheochromocytoma and paraganglioma, PRAD prostate adenocarcinoma, SARC sarcoma, SCM skin cutaneous melanoma, STAD stomach adenocarcinoma, TGCC testicular germ cell cancer, THRC thyroid carcinoma, Thym thymoma, UCEC uterine corpus endometrial carcinoma, UTCA uterine carcinosarcoma, UVME uveal melanoma. n, number of samples. d DEK vs. CELF1 mRNA in uveal melanoma (n = 80), prostate adenocarcinoma (n = 498) and colorectal adenocarcinoma (n = 382) patients (data obtained from TCGA) shown on correlation scatter plots