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. 2017 Dec 21;7:17987. doi: 10.1038/s41598-017-18178-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Econazole induces apoptosis in lung cancer cell lines. (A) Econazole induced apoptosis in H661 and A549 lung cancer cells. H661 and A549 cells were treated with econazole at 0.5, 5, 10, or 20 μM for 24 hours. Apoptosis was measured by Annexin V/PI staining. (B) Econazole induced the cleavage of Caspase-3 and PARP in lung cancer cells, as measured by Western blotting. H661 and A549 cells were treated with econazole (1.25, 2.5, 5, or 10 μM) for 24 hours. Normalized band intensities were added below cleaved PARP and Caspase-3.